Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data

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Title Differential DNA methylation profiles in gynecological cancers and correlation with clinico-pathological data

Background: Epigenetic gene silencing is one of the major causes of carcinogenesis. Its widespread occurrence in cancer genome could inactivate many cellular pathways including DNA repair, cell cycle control, apoptosis, cell adherence, and detoxification. The abnormal promoter methylation might be a potential molecular marker for cancer management. Methods: For rapid identification of potential...

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  Background and Objectives: The most prevalent malignancy among women is known to be breast cancer (BC). Several factors contribute to determining tumor prognosis and treatment strategies. In this study, the frequency and relevance of these factors are discussed. Materials and Methods: This cross-sectional study was carried out on 214 patients with BC, who referred to the Cancer Institute of...

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BACKGROUND Cutaneous vasculitis presents as a mosaic of clinical and histological findings. Its pathogenic mechanisms and clinical manifestations are varied. AIMS To study the epidemiological spectrum of cutaneous vasculitides as seen in a dermatologic clinic and to determine the clinico-pathological correlation. METHODS A cohort study was conducted on 50 consecutive patients clinically dia...

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Emerging Patterns in Clinico-pathological spectrum of Oral Cancers

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ژورنال

عنوان ژورنال: BMC Cancer

سال: 2006

ISSN: 1471-2407

DOI: 10.1186/1471-2407-6-212